SELECTED PUBLICATIONS

    Bioavailability

    Reynolds LM, Lau M, Brown R, Luks A, Sharma M, Fisher DM: Bioavailability of intramuscular rocuronium in infants and children. Anesthesiology 87:1096-1105, 1997 abstract

    Censored Data

    Luks AM, Zwass MS, Brown RC, Lau M, Chari G, Fisher DM: Opioid-induced analgesia in neonatal dogs: Pharmacodynamic differences between morphine and fentanyl. J Pharmacol Exp Ther 284:136-141, 1998 abstract

    Metabolites

    Caldwell JE, Szenohradszky J, Segredo V, Wright PMC, McLoughlin C, Sharma ML, Gruenke LD, Fisher DM, Miller RD. The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers. J Pharmacol Exp Ther 270:1216-1222, 1994 abstract

    Wright PMC, Hart P, Lau M, Sharma M, Gruenke L, Fisher DM: Cumulative characteristics of atracurium and vecuronium: A simultaneous clinical and pharmacokinetic study. Anesthesiology 81:59-68, 1994 abstract

    Mixed-effects Linear Regression

    Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA: Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 279:217-221, 1998 abstract

    Romson JL, Leung JM, Bellows WH, Bronstein M, Keith F, Moore W, Flachsbart K, Richter R, Pastor D, Fisher DM: Effects of dobutamine on hemodynamics and left ventricular performance in cardiac surgical patients. Anesthesiology 91:1318-28, 1999 abstract

    Pharmacodynamic Modeling

    Fisher DM, Rosen JI: A pharmacokinetic explanation for increasing recovery time following larger or repeated doses of nondepolarizing muscle relaxants. Anesthesiology 65:286-291, 1986 abstract

    Bragg P, Zwass MS, Lau M, Fisher DM: Opioid pharmacodynamics in neonatal dogs: Differences between morphine and fentanyl. J Appl Physiol 79:1519-1524, 1995 abstract

    Fisher DM, Szenohradzky J, Wright PMC, Lau M, Brown R, Sharma M: Pharmacodynamic modeling of vecuronium-induced twitch depression: Rapid plasma-effect site equilibration explains faster onset at resistant laryngeal muscles than at the adductor pollicis. Anesthesiology 86:558-566, 1997 abstract

    Luks AM, Zwass MS, Brown RC, Lau M, Chari G, Fisher DM: Opioid-induced analgesia in neonatal dogs: Pharmacodynamic differences between morphine and fentanyl. J Pharmacol Exp Ther 284:136-141, 1998 abstract

    Pharmacodynamic Modeling Without Plasma Concentration Data

    Bragg P, Fisher DM, Donati F, Meistelman C, Lau M, Sheiner LB: Comparison of twitch depression of the adductor pollicis and the respiratory muscles: Pharmacodynamic modeling without plasma concentrations. Anesthesiology 80:310-319, 1994 abstract

    Fisher DM, Wright PMC: Are plasma concentration values necessary for pharmacodynamic modeling of muscle relaxants? Anesthesiology 86:567-575, 1997 abstract

    Wright PMC, Brown R, Lau M, Fisher DM: A pharmacodynamic explanation for the rapid onset/offset of rapacuronium bromide. Anesthesiology 90:16-23, 1999 abstract

    Pharmacokinetics

    Birmingham PK, Tobin MJ, Henthorn TK, Fisher DM, Berkelhamer MC, Smith FA, Fanta KB, Coté CJ: Twenty-four hour pharmacokinetics of rectal acetaminophen in children: An old drug with new recommendations. Anesthesiology 87:244-252, 1997 abstract

    Szenohradszky J, Caldwell LE, Wright PMC, Brown R, Lau M, Luks A, Fisher DM: Influence of renal failure on the pharmacokinetics and neuromuscular effects of a single dose of rapacuronium bromide. Anesthesiology 90:24-35, 1999 abstract

    Fisher DM, Kahwaji R, Bevan D, Bikhazi G, Fragen RJ, Angst MS, Ornstein E, Matteo RS: Factors affecting the pharmacokinetic characteristics of rapacuronium. Anesthesiology 90:993-1000, 1999 abstract

    Pharmacokinetic Modeling of Elimination from Peripheral Compartments

    Fisher DM, Canfell PC, Fahey MR, Rosen JI, Rupp SM, Sheiner LB, Miller RD: Elimination of atracurium in humans: Contribution of Hofmann elimination and ester hydrolysis vs. organ-based elimination. Anesthesiology 65:6-12, 1986 abstract

    Fisher DM: (Almost) everything you learned about pharmacokinetics was (somewhat) wrong! Anesth Analg 83:901-903, 1996 abstract

    Pharmacokinetic Modeling During Non-Steady State Conditions

    Shangraw RE, Fisher DM: Pharmacokinetics of dichloroacetate in patients undergoing liver transplantation. Anesthesiology 84: 851-858, 1996 abstract

    Fisher DM, Ramsay MAE, Hein HAT, Marcel RJ, Sharma M, Ramsay KJ, Miller RD: Pharmacokinetics of rocuronium during the three stages of liver transplantation. Anesthesiology 86:1306-1316, 1997 abstract

    Quality Control

    Adams M, Fisher DM, Dumont LJ, Dzik WH, Heaton WA. Detecting failed leukocyte- reduction processes: Computer simulations of intermittent and continuous process failure. Transfusion 40:1427-33, 2000 abstract

    Simulation of Dosing Regimens

    Fisher DM, Reynolds KS, Schmith VD, Hsu J, Sokoll MD, Lennon RL, Caldwell JE: Influence of renal function on the pharmacokinetics and pharmacodynamics and simulated time course of doxacurium. Anesth Analg 89:786-95, 1999 abstract

    Sparse Samping

    Wright PMC, Fisher DM: Can bioavailability of low-variance drugs be estimated with an unpaired, sparse sampling design? Clin Pharmacol Ther 63:437-443, 1998 abstract